Sepsis Six

The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with sepsis.

2011, The UK Sepsis Trust published evidence that use of the Sepsis Six was linked to a 50% reduction in mortality, a decreased length of stay in hospital, and fewer intensive care days.[3] ā€“ findings that have since been replicated around the world.

The Sepsis Six consists of three diagnostic and three therapeutic steps ā€“ all to be delivered within one hour of the initial diagnosis of sepsis:

Titrate oxygen to a saturation target of 94%
Take blood cultures and consider source control
Administer empiric intravenous antibiotics
Measure serial serum lactates
Start intravenous fluid resuscitation
Commence accurate urine output measurement.

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