The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with sepsis.
2011, The UK Sepsis Trust published evidence that use of the Sepsis Six was linked to a 50% reduction in mortality, a decreased length of stay in hospital, and fewer intensive care days. – findings that have since been replicated around the world.
The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis:
Titrate oxygen to a saturation target of 94%
Take blood cultures and consider source control
Administer empiric intravenous antibiotics
Measure serial serum lactates
Start intravenous fluid resuscitation
Commence accurate urine output measurement.